Pharmaceutical labeling dependencies occur when one market’s label needs information from a different market before it can begin work. This typically happens when a country needs to submit a label change and relies on other pieces of information before it can submit. Most of the time, this involves a country that does not have its own regulatory body to do this line of work. The dependent country can leverage the work already performed by its reference country. For example, Costa Rica may wait for another country, like the United States, to approve a drug. Once the United States approves it, Costa Rica will follow along. In other cases, this could be waiting for a translation of the core datasheet into a different language.